Jardiance Duo Contraindications

Hypersensitivity to active ingredients empagliflozin and/or metformin or to any of the excipients.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Diabetic pre-coma.
Patients with CKD stage 4 or 5 (severely impaired renal function including patients receiving dialysis; eGFR < 30 ml/min/1.73m² or ClCr < 30 ml/min) or eGFR persistently < 45 ml/min/ 1.73m² or ClCr persistently < 45 ml/ min (CKD Stage 3B).
Acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock, intravascular administration of iodinated contrast agents (see Precautions).
Acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock, pulmonary embolism, acute significant blood loss, sepsis, gangrene, pancreatitis (see Precautions).
During or immediately following surgery where insulin is essential, elective major surgery.
Hepatic impairment, acute alcohol intoxication, alcoholism (due to metformin component).
Lactation.